The complex pathophysiology of acquired aplastic anaemia.

Abstract

Immune-mediated destruction of haematopoietic stem/progenitor cells (HSPCs) plays a central role in the pathophysiology of acquired aplastic anaemia (aAA). Dysregulated CD8(+) cytotoxic T cells, CD4(+) T cells including T helper type 1 (Th1), Th2, regulatory T cells and Th17 cells, natural killer (NK) cells and NK T cells, along with the abnormal production… (More)
DOI: 10.1111/cei.12605

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@article{Zeng2015TheCP, title={The complex pathophysiology of acquired aplastic anaemia.}, author={Yanjun Zeng and E Katsanis}, journal={Clinical and experimental immunology}, year={2015}, volume={180 3}, pages={361-70} }