The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress.

@article{KoskenkorvaFrank2013TheCI,
  title={The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress.},
  author={Taija S Koskenkorva-Frank and Guenter Weiss and Willem H Koppenol and Susanna Burckhardt},
  journal={Free radical biology & medicine},
  year={2013},
  volume={65},
  pages={
          1174-1194
        }
}
Production of minute concentrations of superoxide (O2(*-)) and nitrogen monoxide (nitric oxide, NO*) plays important roles in several aspects of cellular signaling and metabolic regulation. However, in an inflammatory environment, the concentrations of these radicals can drastically increase and the antioxidant defenses may become overwhelmed. Thus, biological damage may occur owing to redox imbalance-a condition called oxidative and/or nitrosative stress. A complex interplay exists between… CONTINUE READING
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