The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis.

@article{Walsh2010TheCI,
  title={The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis.},
  author={Craig M. Walsh and Aimee L Edinger},
  journal={Immunological reviews},
  year={2010},
  volume={236},
  pages={95-109}
}
Intense research efforts over the last two decades have focused on establishing the significance of apoptotic signaling in adaptive immunity. Without doubt, caspase-dependent apoptosis plays vital roles in many immune processes, including lymphocyte development, positive and negative selection, homeostasis, and self-tolerance. Cell biologists have developed new insights into cell death, establishing that other modes of cell death exist, such as programmed necrosis and type II/autophagic cell… CONTINUE READING

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