The complete sequence of the human CD79b (lgβ/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism
@article{Hashimoto2004TheCS, title={The complete sequence of the human CD79b (lgβ/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism}, author={S. Hashimoto and N. Chiorazzi and P. Gregersen}, journal={Immunogenetics}, year={2004}, volume={40}, pages={145-149} }
We determined the complete genomic sequence of the human CD79b (Igβ/B29) gene. The CD79b gene product is associated with the membrane immunoglobulin signaling complex which is composed of immunoglobulin (Ig) itself, associated in a noncovalent fashion with CD79b and a second polypeptide chain, CD79a (Igα/mb1). The sequence and exon/intron organization of the human and mouse CD79b genes are highly similar. The gene organization suggests that some variant forms of CD79b may arise by virtue of… CONTINUE READING
11 Citations
Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79a (lg-αmb-1) gene
- Biology
- Immunogenetics
- 2004
- 7
Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a)
- Biology
- Proceedings of the National Academy of Sciences of the United States of America
- 2003
- 113
- PDF
The promoter and 5' flanking sequences controlling human B29 gene expression.
- Biology, Medicine
- Blood
- 1996
- 40
- PDF
Molecular characterisation of the CD79a and CD79b subunits of the B cell receptor complex in the gray short-tailed opossum (Monodelphis domestica) and tammar wallaby (Macropus eugenii): Delayed B cell immunocompetence in marsupial neonates.
- Biology, Medicine
- Veterinary immunology and immunopathology
- 2010
- 12
Two sources of programmed flexibility in the immune system: variation in structural and regulatory gene segments
- Biology, Computer Science
- 1997
The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis.
- Biology, Medicine
- Blood
- 2002
- 62
- PDF
Therapeutic targeting of the BCR-associated protein CD79b in a TCR-based approach is hampered by aberrant expression of CD79b.
- Biology, Medicine
- Blood
- 2015
- 12
- PDF
The Value of Anti-Pax-5 Immunostaining in Routinely Fixed and Paraffin-Embedded Sections: A Novel Pan Pre-B and B-Cell Marker
- Biology, Medicine
- The American journal of surgical pathology
- 2002
- 144
- Highly Influenced
Inhibitors of B-cell receptor signaling for patients with B-cell malignancies.
- Biology, Medicine
- Cancer journal
- 2012
- 40
References
SHOWING 1-10 OF 15 REFERENCES
Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).
- Biology, Medicine
- Genomics
- 1993
- 22
The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.
- Biology, Medicine
- Journal of immunology
- 1993
- 26
Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.
- Biology, Medicine
- Journal of immunology
- 1992
- 41
B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1988
- 173
- PDF
Multiple motifs regulate the B-cell-specific promoter of the B29 gene.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1993
- 62
- PDF
Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1989
- 49
- PDF
Recombination between immunoglobulin variable region gene segments is enhanced by transcription
- Medicine, Biology
- Nature
- 1986
- 222
The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene.
- Biology, Medicine
- Journal of immunology
- 1993
- 25
BLyF, a novel cell-type- and stage-specific regulator of the B-lymphocyte gene mb-1.
- Biology, Medicine
- Molecular and cellular biology
- 1992
- 62
- PDF