The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms.

@article{Cladaras1986TheCS,
  title={The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms.},
  author={C Cladaras and Margarita Hadzopoulou-Cladaras and Ronald Nolte and David Atkinson and Vassilis I. Zannis},
  journal={The EMBO journal},
  year={1986},
  volume={5 13},
  pages={
          3495-507
        }
}
We have isolated and sequenced overlapping cDNA clones covering the entire sequence of human apolipoprotein B-100 (apoB-100). DNA sequence analysis and determination of the mRNA transcription initiation site by S1 nuclease mapping showed that the apoB mRNA consists of 14,112 nucleotides including the 5' and 3' untranslated regions which are 128 and 301 nucleotides respectively. The DNA-derived protein sequence shows that apoB-100 is 513,000 daltons and contains 4560 amino acids including a 24… CONTINUE READING
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