The complete genome sequence of the gastric pathogen Helicobacter pylori

  title={The complete genome sequence of the gastric pathogen Helicobacter pylori},
  author={Jean-F. Tomb and O. White and Anthony R. Kerlavage and Rebecca A. Clayton and Granger G. Sutton and Robert D. Fleischmann and Karen A. Ketchum and Hans Peter Klenk and S. Gill and B. Dougherty and K. Nelson and J. Quackenbush and L. Zhou and E. Kirkness and S. Peterson and B. Loftus and D. Richardson and R. Dodson and Hanif G. Khalak and A. Głodek and K. McKenney and Lisa M. Fitzegerald and Norman Lee and M. Adams and Erin K. Hickey and Douglas E. Berg and J. Gocayne and T. Utterback and J. Peterson and Jenny M. Kelley and M. Cotton and J. Weidman and C. Fujii and C. Bowman and Larry Watthey and E. Wallin and William S. Hayes and M. Borodovsky and Peter D. Karp and H. Smith and C. Fraser and J. Venter},
  • Jean-F. Tomb, O. White, +39 authors J. Venter
  • Published 1997
  • Biology, Medicine
  • Nature
  • Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host–pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane… CONTINUE READING
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