The complete genome sequence of Francisella tularensis, the causative agent of tularemia

  title={The complete genome sequence of Francisella tularensis, the causative agent of tularemia},
  author={P{\"a}r Larsson and Petra C. F. Oyston and Patrick Chain and May C. Chu and Melanie Duffield and H. H. Fuxelius and E. Soga Garcia and Greger H{\"a}lltorp and Daniel Johansson and Karen E. Isherwood and Peter D. Karp and Eva Larsson and Yang Liu and Stephen Michell and Joann L. Prior and Richard Prior and Stephanie A. Malfatti and Anders Sj{\"o}stedt and Kerstin Svensson and Nick Thompson and Lisa M. Vergez and Jonathan K Wagg and Brendan W. Wren and Luther E. Lindler and Siv G E Andersson and Mats Forsman and Richard W. Titball},
  journal={Nature Genetics},
Francisella tularensis is one of the most infectious human pathogens known. In the past, both the former Soviet Union and the US had programs to develop weapons containing the bacterium. We report the complete genome sequence of a highly virulent isolate of F. tularensis (1,892,819 bp). The sequence uncovers previously uncharacterized genes encoding type IV pili, a surface polysaccharide and iron-acquisition systems. Several virulence-associated genes were located in a putative pathogenicity… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 207 extracted citations


Publications referenced by this paper.
Showing 1-10 of 54 references

Factors affecting the escape of Francisella tularensis from the phagolysosome

  • H Lindgren
  • J. Med. Microbiol
  • 2004

Gram-negative aerobic cocci

  • A. Sjostedt
  • Family XVII. Francisellaceae. in Bergey’s Manual…
  • 2004

Similar Papers

Loading similar papers…