The complete connectome of a learning and memory centre in an insect brain

@article{Eichler2017TheCC,
  title={The complete connectome of a learning and memory centre in an insect brain},
  author={Katharina Eichler and Feng Yu Li and Ashok Litwin-Kumar and Youngser Park and Ingrid V. Andrade and Casey M Schneider-Mizell and Timo Saumweber and Annina Maria Huser and Claire Eschbach and Bertram Gerber and Richard D Fetter and James W. Truman and Carey E. Priebe and L. F. Abbott and Andreas S. Thum and Marta Zlatic and Albert Cardona},
  journal={Nature},
  year={2017},
  volume={548},
  pages={175-182}
}
Associating stimuli with positive or negative reinforcement is essential for survival, but a complete wiring diagram of a higher-order circuit supporting associative memory has not been previously available. Here we reconstruct one such circuit at synaptic resolution, the Drosophila larval mushroom body. We find that most Kenyon cells integrate random combinations of inputs but that a subset receives stereotyped inputs from single projection neurons. This organization maximizes performance of a… CONTINUE READING
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