The complete chirospectroscopic signature of the peptide 310‐helix in aqueous solution

@article{Toniolo2004TheCC,
  title={The complete chirospectroscopic signature of the peptide 310‐helix in aqueous solution},
  author={C. Toniolo and F. Formaggio and S. Tognon and Q. Broxterman and B. Kaptein and R. Huang and V. Setni{\vc}ka and T. Keiderling and I. McColl and L. Hecht and L. Barron},
  journal={Biopolymers},
  year={2004},
  volume={75}
}
We synthesized by solution methods a water‐soluble, terminally blocked heptapeptide based on five markedly helicogenic, Cα‐tetrasubstituted α‐amino acids Cα‐methyl‐L‐norvalines and two strongly hydrophilic 2‐amino‐3‐[1‐(1,4,7‐triazacyclononane)]‐L‐propanoic acid residues at positions 2 and 5. A Fourier transform infrared absorption and NMR analysis in deuterated chloroform and aqueous solutions of the heptapeptide and two side‐chain protected synthetic precursors confirmed our working… Expand

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