The complement system and age-related macular degeneration

  title={The complement system and age-related macular degeneration},
  author={S. Sivaprasad and N. H. Chong},
  • S. Sivaprasad, N. H. Chong
  • Published 2006
  • Medicine
  • Eye
  • PurposeAge-related macular degeneration (AMD) is the leading cause of blindness in the developed world. There are increasing evidences to suggest the complement system may play a significant role on the pathogenesis of AMD. In this review, we summarise the current research in this area.MethodsReview of literature.ResultsThe complement system is a complex system with several activation pathways. Complement factor H (CFH) polymorphisms has been associated with increase risk of AMD. CFH is an… CONTINUE READING
    44 Citations

    Figures and Topics from this paper

    Complement inhibitors for age-related macular degeneration.
    • 13
    • PDF
    Lutein and Factor D: two intriguing players in the field of age-related macular degeneration.
    • 11
    • PDF
    Oxidative stress: the achilles' heel of neurodegenerative diseases of the retina.
    • 42
    • Highly Influenced
    • PDF
    New therapeutic targets in atrophic age-related macular degeneration
    • K. Petrukhin
    • Medicine
    • Expert opinion on therapeutic targets
    • 2007
    • 56
    Review of Genetics in Age Related Macular Degeneration
    • 94


    Drusen complement components C3a and C5a promote choroidal neovascularization.
    • 364
    • PDF
    Immunological and Aetiological Aspects of Macular Degeneration
    • 443
    A role for local inflammation in the formation of drusen in the aging eye.
    • 950
    A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.
    • 1,804
    • PDF