The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment.

@article{Risitano2012TheCR,
  title={The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment.},
  author={Antonio M Risitano and Rosario Notaro and Caterina Pascariello and Michela Sica and Luigi del Vecchio and Christopher J. Horvath and Masha Fridkis-Hareli and Carmine Selleri and Margaret A Lindorfer and Ronald P Taylor and Lucio Luzzatto and V. Michael Holers},
  journal={Blood},
  year={2012},
  volume={119 26},
  pages={6307-16}
}
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis because of the lack from erythrocyte surface of the complement regulators CD55 and CD59, with subsequent uncontrolled continuous spontaneous activation of the complement alternative pathway (CAP), and at times of the complement classic pathway. Here we investigate in an in vitro model the effect on PNH erythrocytes of a novel therapeutic strategy for membrane-targeted delivery of a CAP… CONTINUE READING