The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci.

@article{Zipfel2008TheCF,
  title={The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci.},
  author={Peter F Zipfel and Teresia Hallstr{\"o}m and Sven Hammerschmidt and Christine Skerka},
  journal={Vaccine},
  year={2008},
  volume={26 Suppl 8},
  pages={
          I67-74
        }
}
Factor H is the central regulator of the alternative complement pathway and controls early activation of the complement cascade at the level of the C3 convertase. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), as well as the more frequent retinal disease age related macular degeneration (AMD). In addition… CONTINUE READING
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