The complement abnormalities of lipodystrophy.

@article{Sissons1976TheCA,
  title={The complement abnormalities of lipodystrophy.},
  author={J. G. Sissons and Robert J West and J Fallows and David G. Williams and Barbara J. Boucher and Nick Amos and Dr T. K. Peters},
  journal={The New England journal of medicine},
  year={1976},
  volume={294 9},
  pages={461-5}
}
Investigation of the serum complement system in 25 patients with various forms of lipodystrophy showed no abnormality in three patients with total lipodystrophy; a single patient with limb lipodystrophy had evidence of activation of the classical complement pathway. However, of the 21 patients with partial lipodystrophy, 17 had low serum C3, with normal C4 and C2, concentrations, accompanied in 14 by a serum C3 splitting factor indistinguishable from nephritic factor, suggesting activation of… CONTINUE READING

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