The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents

@article{Schmutz1990TheCN,
  title={The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents},
  author={Markus Schmutz and Ch. Portet and A. Jeker and Klaus Klebs and Annick Vassout and Hans Allgeier and Roland Heckendorn and Graham E. Fagg and H.-R. Olpe and Henk van Riezen},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1990},
  volume={342},
  pages={61-66}
}
Anticonvulsant properties of CGP 37849 and CGP 39551, two novel phosphono-amino acids which are competitive NMDA receptor antagonists, were examined in rodents. At optimal pretreatment times CGP 37849 suppressed electroshock-induced seizures in mice and rats with ED50 s ranging from 8 to 22 mg/kg after oral administration, and 0.4 to 2.4 mg/kg after i. v. and i. p. injection. Relative to CGP 37849, CGP 39551 was more potent after p. o. (ED50 3.7–8.1 mg/kg), and less potent after i.v. or i.p… CONTINUE READING

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