The comparison of vanadyl (IV) and insulin-induced hyperpolarization of the mammalian muscle cell.


Extracellularly applied vanadyl (IV) hyperpolarized the membrane potential of mouse diaphragm muscle from about -74.0 mV up to -81.7 mV. The hyperpolarizing effect of 10(-4) mol.I-1 vanadyl (IV) is comparable with hyperpolarization induced by 100 insulin. Both compounds increased the intracellular K+ concentration, the hyperpolarizing effect of… (More)


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