OBJECTIVE To study the 4 different processing methods of Dendrobium loddigesii. and find a optimal method. METHODS Drying in the shade, fire drying at different temperature, twist and fire drying, to scald by boiling water then twist and fire drying were used to process D. loddigesii and determined the content of polysaccharide after processed. RESULTS The rate of dryed medical material was about 36%, and the content of polysaccharide was 16.39% which was scald by boiling water then twist and fire drying was higher than others. CONCLUSION The method scald by boiling water then twist and fire drying is good for medical materials dried and the remaining of active component. It provide a scientific evidence to Chinese Pharmacopoeia 2005 and offer quantization index to the processing of Dendrobium loddigesii.