The comparative proteomics of ubiquitination in mouse.

  title={The comparative proteomics of ubiquitination in mouse.},
  author={C. A. M. Semple},
  journal={Genome research},
  volume={13 6B},
Ubiquitination is a common posttranslational modification in eukaryotic cells, influencing many fundamental cellular processes. Defects in ubiquitination and the processes it mediates are involved in many human disease states. The ubiquitination of a substrate involves four classes of enzymes:a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), a ubiquitin protein ligase (E3), and a de-ubiquitinating enzyme (DUB). A substantial number of E1s (four), E2s (13), E3s (97), and… CONTINUE READING

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