The comparative pharmacokinetics and tissue penetration of four quinolones including intravenously administered enoxacin

@article{Wise2005TheCP,
  title={The comparative pharmacokinetics and tissue penetration of four quinolones including intravenously administered enoxacin},
  author={Richard J. S. Wise and D. Lister and Cliodna A M Mcnulty and Deborah J. Griggs and J. M. Andrews},
  journal={Infection},
  year={2005},
  volume={14},
  pages={S196-S202}
}
SummaryThe pharmacokinetics and tissue penetration of four quinolones were studied. The compounds were norfloxacin (400 mg p.o.), enoxacin (600 mg p.o. and 400 mg i.v.), ciprofloxacin (100 mg i.v. and 500 mg p.o.) and ofloxacin (600 mg p.o.) given to healthy volunteers. Of the oral agents studied ofloxacin and ciprofloxacin were the most rapidly absorbed (Tmax 1.2 h) and enoxacin the least (Tmax 1.9 h). The serum levels attained were highest in the case of ofloxacin (after allowing for the… 
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