The comparative pharmacokinetics and tissue penetration of four quinolones including intravenously administered enoxacin

  title={The comparative pharmacokinetics and tissue penetration of four quinolones including intravenously administered enoxacin},
  author={Richard J. S. Wise and D. Lister and Cliodna A M Mcnulty and Deborah J. Griggs and J. M. Andrews},
SummaryThe pharmacokinetics and tissue penetration of four quinolones were studied. The compounds were norfloxacin (400 mg p.o.), enoxacin (600 mg p.o. and 400 mg i.v.), ciprofloxacin (100 mg i.v. and 500 mg p.o.) and ofloxacin (600 mg p.o.) given to healthy volunteers. Of the oral agents studied ofloxacin and ciprofloxacin were the most rapidly absorbed (Tmax 1.2 h) and enoxacin the least (Tmax 1.9 h). The serum levels attained were highest in the case of ofloxacin (after allowing for the… 
Comparative Bioavailability of Norfloxacin Tablets Based on Blood and Urine Data
Urinary excretion of norfloxacin may be a useful noninvasive tool for bioavailability assessment of nor Floxin oral formulations and bioequivalence could not be established among the three tested products.
Comparative Pharmacokinetics of New Quinolones
The pharmacokinetic properties of the new quinolones are characterised by a high volume of distribution, long biological half-life, low serum protein binding, elimination mainly by the kidneys, high total and renal clearances and a moderate to excellent bioavailability after oral administration.
In vitro study of the interaction between some fluoroquinolones and extracts of kola nitida seed
The cup diffusion method was used to evaluate the in vitro interaction of some fluoroquinolones with extracts of Kola nitida seed and revealed that the MIC of the drugs decreased when combined with KNS extract.
A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
A simple assay method using reversed-phase high-performance liquid chromatography and perchloric acid precipitation for sample pre-treatment to assess changes in CYP1A2 activity in healthy subjects can be applied to the pharmacokinetic study of norfloxacin and en oxacin after repeated administration.
Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance
Safe and cheap fluoroquinolone, such as enoxacin, might be used for the treatment of clinical cases caused by Babesia spp.
Diversidade genética, fatores de virulência e perfis de susceptibilidade a antimicrobianos de isolados de Escherichia coli provenientes do útero, da boca e das fezes de cadelas com piometra
Three animals showed strong similarity among E. coli strains isolated from intrauterine contents and mouth, and the major risks facing the large number of UVF and multidrug resistance found in the E.coli strains recovered from the pet samples were highlighted.
Uncertainty and variability in human exposure limits – a chemical-specific approach for ciprofloxacin and methotrexate
A probabilistic approach for human hazard characterization and the derivation of HELs is elaborated, which extends the framework for evaluating and expressing uncertainty in hazard characterization recently proposed by WHO-IPCS by the incorporation of chemical-specific data on human variability in toxicokinetics.
Resistenzsteigerung vom Mehrschrittyp bei in vitro wiederholt subinhibitorischen Konzentrationen von Zweitgenerationschinolonen ausgesetzten Neisseria gonorrhoeae-Isolaten
It seems remarkable that even at the end of the experiments no strain grew at concentrations of ciprofloxacin exceeding 0.064 mg/l, which means quick development of resistance need not be expected after the introduction of newer quinolones into the therapy of gonorrhoea on a large scale.


Pharmacokinetics and tissue penetration of enoxacin
The pharmacokinetics of the quinolone enoxacin were studied after a 600-mg oral dose was given to each of six male volunteers. The levels of the compound were measured in serum, blister fluid, and
The pharmacokinetics and tissue penetration of ofloxacin.
The pharmacokinetics of the 4-quinolone agent, ofloxacin, were studied in six healthy volunteers, following a 600 mg oral dose, by a microbiological assay in serum, blister fluid and urine.
The pharmacokinetics and tissue penetration of norfloxacin.
The pharmacokinetics and cantharides-induced blister fluid levels of norfloxacin were studied after a single 400 mg oral dose and the blister fluid level exceeded the serum level, both declining in parallel.
Pharmacokinetics and tissue penetration of ciprofloxacin.
A 500-mg dose of the quinoline ciprofloxacin was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and blister fluid were measured.
In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid
Ciprofloxacin would seem to be a promising antibacterial agent for the treatment of urinary tract infection.
In-vitro activity of enoxacin (CL-919), a new quinoline derivative, compared with that of other antimicrobial agents.
Gentamicin-resistant strains of common bacterial pathogens were susceptible to enoxacin as were methicillin-resistant Staph.
Pharmacokinetics of intravenously administered ciprofloxacin
A 100-mg dose of ciprofloxacin was given as an intravenous bolus injection to each of six healthy volunteers, after which the levels of this agent were measured in serum, blister fluid, and urine.
In vitro antibacterial properties of AT-2266, a new pyridonecarboxylic acid.
A new pyridonecarboxylic acid derivative with broad and potent antibacterial activity, AT-2266 inhibited some gram-positive bacteria, such as staphylococci and Bacillus subtilis, and most gram-negative bacteria, including Serratia marcescens, Pseudomonas aeruginosa, Haemophilus influenzae, and Campylobacter jejuni.
The antimicrobial spectrum of norfloxacin.
  • S. Newsom
  • Biology, Medicine
    The Journal of antimicrobial chemotherapy
  • 1984
The wide spectrum of norfloxacin should make it useful for therapy of urinary tract infection, and for gut decontamination and enteric infections, and the high potency should allow use of lower doses with possibly less toxicity than nalidixic acid.
In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim
  • N. Chin, H. Neu
  • Biology, Medicine
    Antimicrobial Agents and Chemotherapy
  • 1983
Enoxacin inhibited organisms resistant to cefotaxime, moxalactam, gentamicin, and piperacillin, but serum did not decrease minimal inhibitory concentrations or minimal bactericidal concentrations, and resistance frequency development was less than 10(-9) for most bacterial species.