The comparative method rules! Codon volatility cannot detect positive Darwinian selection using a single genome sequence.

@article{Dagan2005TheCM,
  title={The comparative method rules! Codon volatility cannot detect positive Darwinian selection using a single genome sequence.},
  author={Tal Dagan and Dan Graur},
  journal={Molecular biology and evolution},
  year={2005},
  volume={22 3},
  pages={496-500}
}
All established methods for detecting positive selection at the molecular level rely on comparisons between nucleotide sequences. An exceptional method that purports to detect selection on the basis of a single genomic sequence has recently been proposed. This method uses a measure called "codon volatility," defined for each codon as the ratio between the number of nonsynonymous codons that differ from the codon under study at a single nucleotide position and the number of sense codons that… CONTINUE READING

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