The comparative effects of tumor-related agents on developmental marker expression in presumptive myoblasts and myotubes.

The effect of a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), on differentiation marker expression in skeletal myotubes and their immediate progenitors, presumptive myoblasts (PMbs), was investigated. The markers employed included the K-isozyme of pyruvate kinase (PK-K) and a newly characterized phosphoprotein (pp(65;4.5)), which are both… CONTINUE READING