The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart.

@article{Liu2012TheCE,
  title={The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart.},
  author={Le Liu and Yun Qiang Xia and Ying Chen and Quanguang Wang and Tong Shi and Fangyan Wang and Robert H Small and Xuzhong Xu},
  journal={Anesthesia and analgesia},
  year={2012},
  volume={114 4},
  pages={886-93}
}
BACKGROUND It remains unclear whether lipid combined with epinephrine is superior or inferior to either drug alone in treating bupivacaine cardiotoxicity. We compared the effects of lipid, epinephrine, and the combination of the two in reversing bupivacaine-induced asystole in the isolated rat heart model. We also measured the effects of lipid, epinephrine, and the combination of the two on bupivacaine content in cardiac tissue. METHODS Hearts from male Sprague-Dawley rats were excised and… CONTINUE READING

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