The comparative effectiveness of hydrochlorothiazide and chlorthalidone in an observational cohort of veterans.

@article{Lund2012TheCE,
  title={The comparative effectiveness of hydrochlorothiazide and chlorthalidone in an observational cohort of veterans.},
  author={Brian C. Lund and Michael E. Ernst},
  journal={Journal of clinical hypertension},
  year={2012},
  volume={14 9},
  pages={623-9}
}
Indirect evidence suggests that chlorthalidone may be more effective than hydrochlorothiazide (HCTZ), but direct comparisons are lacking. Using national Veterans Administrative pharmacy data from 2003 to 2008, the authors performed a retrospective cohort study examining the effectiveness of chlorthalidone and HCTZ among new thiazide users. For 1 year following the thiazide start, rates of persistence of thiazide use, adequacy of response (defined as the absence of additional new… CONTINUE READING

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