The common variant Q192R at the paraoxonase 1 (PON1) gene and its activity are responsible for a portion of the altered antioxidant status in type 2 diabetes.

@article{Zargari2016TheCV,
  title={The common variant Q192R at the paraoxonase 1 (PON1) gene and its activity are responsible for a portion of the altered antioxidant status in type 2 diabetes.},
  author={Mehryar Zargari and Fahimeh Sharafeddin and Abdolkarim Mahrooz and Ahad Alizadeh and Parisa Masoumi},
  journal={Experimental biology and medicine},
  year={2016},
  volume={241 14},
  pages={1489-96}
}
In this study, we investigated the effects of paraoxonase 1 (PON1) activities and the variant PON1-Q192R on the ferric reducing ability of plasma (FRAP) and total thiol. In addition, we examined the distribution of genotypes of this variant and the relationship of the genotypes with age in patients with type 2 diabetes (T2D). A total of 115 patients with T2D were enrolled in this study. Paraoxonase activity (PON-para) and arylesterase activity (PON-aryl) were determined using spectrophotometric… CONTINUE READING
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