The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.

@article{Levine2009TheCM,
  title={The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.},
  author={Arnold J. Levine},
  journal={Virology},
  year={2009},
  volume={384 2},
  pages={285-93}
}
The small DNA tumor viruses, Polyoma virus, Simian Vacuolating Virus 40, the Papilloma viruses and the human Adenoviruses, were first described during a period of intense virus discovery (1930-1960s) and shown to produce tumors in animals. In each of these cases the viral DNA was shown to persist (commonly integrated into a host chromosome) and only a selected portion of this DNA was expressed as m-RNA and proteins in these cancers. The viral encoded tumor antigens were identified and shown to… CONTINUE READING
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