The combined use of radiation therapy and lonidamine in the treatment of brain metastases

@article{DeAngelis1989TheCU,
  title={The combined use of radiation therapy and lonidamine in the treatment of brain metastases},
  author={Lisa M DeAngelis and Violante E. Currie and Jae-ho Kim and George Krol and Maureen A. O'Hehir and Fouad M. Farag and Charles W. Young and Jerome B. Posner},
  journal={Journal of Neuro-Oncology},
  year={1989},
  volume={7},
  pages={241-247}
}
Lonidamine is an indazole carboxylic acid that has been shown to be synergistic with radiotherapy (RT) in tissue culture and animal models. Clinical experience has shown that lonidamine is well-tolerated, and appears to potentiate the activity of conventional chemotherapy in the treatment of brain metastases. A prospective randomized trial was undertaken to… CONTINUE READING