The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval.

@article{Beasley2005TheCU,
  title={The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval.},
  author={Charles M. Beasley and Malcolm I. Mitchell and Alex A Dmitrienko and Jeffrey T Emmick and Wei Shen and Timothy M. Costigan and Alun Bedding and Michael A. Turik and Arash Bakhtyari and Margaret R Warner and Jeremy N. Ruskin and Louis R. Cantilena and Robert A. Kloner},
  journal={Journal of the American College of Cardiology},
  year={2005},
  volume={46 4},
  pages={678-87}
}
OBJECTIVES This study was designed to evaluate effects of tadalafil, a phosphodiesterase-5 inhibitor used for the treatment of erectile dysfunction (ED), on the QT interval. BACKGROUND Cardiovascular disease is common in men with ED. Men with cardiovascular disease and ED may have decreased cardiac repolarization reserve. METHODS Effects of tadalafil (100 mg by mouth), ibutilide (0.002 mg/kg intravenously), and placebo on the QT interval in healthy men were compared (placebo and tadalafil… CONTINUE READING

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