The combined use of an immunotoxin and a radioimmunoconjugate to treat disseminated human B-cell lymphoma in immunodeficient mice.

@article{Wei2000TheCU,
  title={The combined use of an immunotoxin and a radioimmunoconjugate to treat disseminated human B-cell lymphoma in immunodeficient mice.},
  author={B R Wei and M A Ghetie and Ellen S. Vitetta},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 2},
  pages={631-42}
}
Immunoconjugates (ICs) consist of a targeting moiety and a toxic moiety and have the specificity that traditional cancer therapy lacks. At appropriate doses, ICs are safe and effective in treating various cancers in experimental animals and in humans. However, because cures are rarely achieved using single agents, regimens involving combinations of agents with different mechanisms of action must be evaluated. In this study, we explored the efficacy and toxicity of a combination of two IC… CONTINUE READING
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Immunotoxin therapy: past lessons and future direction

  • E. S. Vitetta, M. A. Ghetie, V. Ghetie
  • Clin Cancer Res
  • 1997
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