The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human α-crystallin.

@article{Nahomi2013TheCE,
  title={The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human α-crystallin.},
  author={Rooban B. Nahomi and Tomoko Oya-Ito and Ram H Nagaraj},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1832 1},
  pages={195-203}
}
N(ε)-acetylation occurs on select lysine residues in α-crystallin of the human lens and alters its chaperone function. In this study, we investigated the effect of N(ε)-acetylation on advanced glycation end product (AGE) formation and consequences of the combined N(ε)-acetylation and AGE formation on the function of α-crystallin. Immunoprecipitation experiments revealed that N(ε)-acetylation of lysine residues and AGE formation co-occurs in both αA- and αB-crystallin of the human lens. Prior… CONTINUE READING
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