The combinations of TNFalpha-308 and IL-6 -174 or IL-10 -1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer's disease.

@article{Vural2009TheCO,
  title={The combinations of TNFalpha-308 and IL-6 -174 or IL-10 -1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer's disease.},
  author={Pervin Vural and Sevgin Değirmencioğlu and Hande Parildar-Karpuzoğlu and Semra Doğru-Abbasoğlu and Hasmet Ayhan Hanagasi and Berrin Karadağ and Hakan G{\"u}rvit and Murat Emre and Mujdat Uysal},
  journal={Acta neurologica Scandinavica},
  year={2009},
  volume={120 6},
  pages={396-401}
}
OBJECTIVE Single nucleotide polymorphisms in the regulatory regions of the cytokine genes for tumor necrosis factor alpha (TNFalpha), interleukin (IL)-6 and IL-10 have been suggested to influence the risk of Alzheimer's disease (AD) with conflicting results. AIM To investigate the TNFalpha-308, IL-6 -174 and IL-10 -1082 gene polymorphisms as susceptibility factors for AD. METHODS We analyzed genotype and allele distributions of these polymorphisms in 101 sporadic AD patients and 138 healthy… CONTINUE READING

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