The combination of prolinoamino acids and cyclopropylamino acids leads to fully functionalized, stable β-turns in water.

@article{Guitot2011TheCO,
  title={The combination of prolinoamino acids and cyclopropylamino acids leads to fully functionalized, stable β-turns in water.},
  author={Karine Guitot and Maud Larregola and Tarun K Pradhan and Jean-Luc Vasse and Solange Lavielle and Philippe Bertus and Jan Szymoniak and Olivier Lequin and Philippe Karoyan},
  journal={Chembiochem : a European journal of chemical biology},
  year={2011},
  volume={12 7},
  pages={1039-42}
}
The conformational freedom of peptides is often considered a major drawback in their use as suitable therapeutic agents. Indeed, flexibility both of backbone and of amino acid side chains is associated with low selectivity, together with poor metabolic stability. However, this flexibility is also responsible for the high affinities of peptides for their… CONTINUE READING