The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate.


The excessive release of glutamate during cerebral ischemia may play an important role in subsequent neuronal injury. Both lamotrigine and hypothermia have independently been shown to attenuate the release of glutamate. In this study, the authors sought to determine whether these effects were additive. Thirty-five New Zealand White rabbits were randomized… (More)


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