The combination of ionizing radiation and expression of a wild type p53 gene via recombinant adenovirus induced a prominent tumour suppressing effect in human oral squamous cell carcinoma.

@article{Wakasa2002TheCO,
  title={The combination of ionizing radiation and expression of a wild type p53 gene via recombinant adenovirus induced a prominent tumour suppressing effect in human oral squamous cell carcinoma.},
  author={Toru Wakasa and Toshiaki Inoue and Naoki Kawai and Jun Murakami and Kazushi Kishi and Kazuhiro Fukui},
  journal={The British journal of radiology},
  year={2002},
  volume={75 896},
  pages={657-62}
}
Human oral squamous cell carcinoma (SCC) cell lines HSC4 and SAS were infected with wild type p53 (wt-p53)-encoding adenovirus (AxCAip53) and subsequently irradiated to investigate the effectiveness of p53 gene therapy in combination with radiation therapy for treating oral SCC. Western blot analysis using anti-p53 monoclonal antibody showed that a large amount of mutant p53 protein was accumulated in HSC4 cells, while no detectable p53 protein was observed in SAS cells. The induction of p53… CONTINUE READING
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