The combination of UCN-01 and ATRA triggers differentiation in ATRA resistant acute promyelocytic leukemia cell lines via RAF-1 independent activation of MEK/ERK.

@article{Liang2019TheCO,
  title={The combination of UCN-01 and ATRA triggers differentiation in ATRA resistant acute promyelocytic leukemia cell lines via RAF-1 independent activation of MEK/ERK.},
  author={Cui Liang and Ming Ding and Xiang-Qin Weng and Y. Sheng and Jing Wu and X. Cai},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2019},
  volume={126},
  pages={
          303-312
        }
}
  • Cui Liang, Ming Ding, +3 authors X. Cai
  • Published 2019
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
With the introduction of arsenic trioxide and all-trans retinoic acid, the prognosis of acute promyelocytic leukemia has greatly improved. However, all-trans retinoic acid resistance is still unresolved in acute promyelocytic leukemia relapsed patients. In this study, the clinical achievable concentration of 7-hydroxystaurosporine synergized with all-trans retinoic acid to induce terminal differentiation in all-trans retinoic acid resistant acute promyelocytic leukemia cell lines. Though 7… Expand
Enzastaurin enhances ATRA-induced differentiation of acute myeloid leukemia cells.

References

SHOWING 1-10 OF 57 REFERENCES
PML-RARα inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia
  • K. Ohnishi
  • Medicine
  • International Journal of Clinical Oncology
  • 2007
...
1
2
3
4
5
...