The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells.

@article{Horinaka2005TheCO,
  title={The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells.},
  author={Mano Horinaka and Tatsushi Yoshida and Takumi Shiraishi and Susumu Nakata and Miki Wakada and Ryoko Nakanishi and Hoyoku Nishino and Toshiyuki Sakai},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={333 3},
  pages={833-8}
}
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one of the most promising candidates for cancer therapeutics. However, some tumor cells are resistant to TRAIL-induced apoptosis. Our previous studies have shown that luteolin, a naturally occurring flavonoid, induces the up-regulation of death receptor 5 (DR5), which is a receptor for TRAIL. Here, we show for the first time that luteolin synergistically acts with exogenous soluble recombinant human TRAIL to induce apoptosis in… CONTINUE READING

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