The combination of IFN-alpha2 and IFN-alpha8 exhibits synergistic antiproliferative activity on renal cell carcinoma (RCC) cell lines through increased binding affinity for IFNAR-2.

@article{Tanimoto2007TheCO,
  title={The combination of IFN-alpha2 and IFN-alpha8 exhibits synergistic antiproliferative activity on renal cell carcinoma (RCC) cell lines through increased binding affinity for IFNAR-2.},
  author={Tadao Tanimoto and Shigeto Yamamoto and Madoka Taniai and Mutsuko Taniguchi and Harumi Ariyasu and Chie Ushio and Miho Aga and Yohei Mukai and Yasuo M Tsutsumi and Toshio Ariyasu and Tsunetaka Ohta and Shigeharu Fukuda},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2007},
  volume={27 6},
  pages={
          517-23
        }
}
  • Tadao Tanimoto, Shigeto Yamamoto, +9 authors Shigeharu Fukuda
  • Published in
    Journal of interferon…
    2007
  • Biology, Medicine
  • Although there are at least 13 interferon-alpha (IFN-alpha) subtypes in humans, interactions between the subtypes remain unknown. To understand IFN-alpha interactions, we examined the antiproliferative activities and the receptor binding affinities of different combinations of IFN-alpha2 and IFN-alpha8 using six renal cell carcinoma (RCC) cell lines. Although IFN-alpha8 was the more potent subtype, synergistic and antagonistic antiproliferative effects were also observed in certain combinations… CONTINUE READING

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