The combination of IκB kinase β inhibitor and everolimus modulates expression of interleukin-10 in human T-cell lymphotropic virus type-1-infected T cells.

@article{Nishioka2013TheCO,
  title={The combination of IκB kinase β inhibitor and everolimus modulates expression of interleukin-10 in human T-cell lymphotropic virus type-1-infected T cells.},
  author={Chie Nishioka and Takayuki Ikezoe and Jing Yang and Keiko Udaka and Akihito Yokoyama},
  journal={Immunology},
  year={2013},
  volume={138 3},
  pages={216-27}
}
Adult T-cell leukaemia-lymphoma (ATLL) is an aggressive malignancy of CD4(+)  CD25(+) T lymphocytes, characterized by a severely compromised immunosystem, in which the human T-cell lymphotropic virus type 1 (HTLV-1) has been recognized as the aetiological agent. This study found that an IκB kinase β (IKKβ) inhibitor Bay11-7082 inactivated mammalian target… CONTINUE READING