The colorectal tumour suppressor APC is present in the NMDA-receptor-PSD-95 complex in the brain.

@article{Yanai2000TheCT,
  title={The colorectal tumour suppressor APC is present in the NMDA-receptor-PSD-95 complex in the brain.},
  author={Hideyuki Yanai and Kiyotoshi Satoh and Akihiko Matsumine and Tetsu Akiyama},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2000},
  volume={5 10},
  pages={815-22}
}
BACKGROUND The synaptic protein PSD-95/SAP90 interacts with ion channels such as the N-methyl-D-aspartate-receptor (NMDA-R) via its PDZ domain, and is involved in their clustering. Moreover, it interacts with signalling molecules and plays an important role in coupling NMDA-R to pathways that control synaptic plasticity and learning. RESULTS We report that PSD-95 interacts with the adenomatous polyposis coli (APC) tumour suppressor protein via its PDZ domain. Furthermore, we found that PSD-95… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

PSD-95 alters microtubule dynamics via an association with EB3.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 4 Excerpts
Highly Influenced

Activity-independent regulation of dendrite patterning by postsynaptic density protein PSD-95.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 1 Excerpt

Similar Papers

Loading similar papers…