The colorectal adenoma-carcinoma sequence.

  title={The colorectal adenoma-carcinoma sequence.},
  author={Amy Leslie and Francis A. Carey and Norman R. Pratt and Robert J. C. Steele},
  journal={The British journal of surgery},
  volume={89 7},
BACKGROUND It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance. METHODS Medline searches were used to identify recent key articles relating to the adenoma-carcinoma sequence. Further pertinent articles were obtained by manual… CONTINUE READING
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