The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand.

@article{Rettenmier1988TheCF,
  title={The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand.},
  author={Carl W. Rettenmier and Martine F Roussel and Charles J Sherr},
  journal={Journal of cell science. Supplement},
  year={1988},
  volume={9},
  pages={27-44}
}
Alterations in genes that function in normal growth and development have been linked to malignant cell transformation. The mononuclear phagocyte colony-stimulating factor (CSF-1 or M-CSF) is a polypeptide growth factor synthesized by mesenchymal cells, which stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series. Multiple forms of soluble CSF-1 are produced by proteolytic cleavage of membrane-bound precursors, some of which are… CONTINUE READING

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