The colonization of Peyer's patches by a strain of Salmonella typhimurium cured of the cryptic plasmid.

Abstract

We cured a strain of Salmonella typhimurium of its cryptic plasmid and confirmed that orally administered cured strains lost virulence for mice. Loss of the cryptic plasmid rendered the S. typhimurium strain sensitive to the bactericidal action of normal human serum. However, loss of the plasmid did not change the ability of the strain to associate with… (More)

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