The collagen repeat sequence is a determinant of the degree of herpesvirus saimiri STP transforming activity.

@article{Choi2000TheCR,
  title={The collagen repeat sequence is a determinant of the degree of herpesvirus saimiri STP transforming activity.},
  author={John Kim Choi and Satoshi Ishido and Jae U Jung},
  journal={Journal of virology},
  year={2000},
  volume={74 17},
  pages={8102-10}
}
Herpesvirus saimiri (HVS) is divided into three subgroups, A, B, and C, based on sequence divergence at the left end of genomic DNA in which the saimiri transforming protein (STP) resides. Subgroup A and C strains transform primary common marmoset lymphocytes to interleukin-2-independent growth, whereas subgroup B strains do not. To investigate the nononcogenic phenotype of the subgroup B viruses, STP genes from seven subgroup B virus isolates were cloned and sequenced. Consistent with the lack… CONTINUE READING
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