The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis

  title={The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis},
  author={S. Kim and Sang-Min Cho and H. Kim and Heon Seok and Taeg Kyu Kwon and J. Chang},
  journal={Experimental & Molecular Medicine},
  • S. Kim, Sang-Min Cho, +4 authors J. Chang
  • Published 2013
  • Biology, Medicine
  • Experimental & Molecular Medicine
  • New colchicine analogs have been synthesized with the aim of developing stronger potential anticancer activities. Among the analogs, CT20126 has been previously reported to show immunosuppressive activities. Here, we report that CT20126 also shows potential anticancer effects via an unusual mechanism: the modulation of microtubule integrity and cell cycle arrest at the G2/M phase before apoptosis. When we treated COS-7 cells with CT20126 (5 μM), the normal thread-like microtubules were… CONTINUE READING
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