The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks.

@article{Mangan2003TheCF,
  title={The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks.},
  author={Shmoolik Mangan and Alon Zaslaver and Uri Alon},
  journal={Journal of molecular biology},
  year={2003},
  volume={334 2},
  pages={197-204}
}
Recent analysis of the structure of transcription regulation networks revealed several "network motifs": regulatory circuit patterns that occur much more frequently than in randomized networks. It is important to understand whether these network motifs have specific functions. One of the most significant network motifs is the coherent feedforward loop, in which transcription factor X regulates transcription factor Y, and both jointly regulate gene Z. On the basis of mathematical modeling and… CONTINUE READING
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