The cognitive profile of ALS: a systematic review and meta-analysis update

@article{Beeldman2015TheCP,
  title={The cognitive profile of ALS: a systematic review and meta-analysis update},
  author={Emma Beeldman and Joost Raaphorst and Michelle Klein Twennaar and Marianne de Visser and Ben Schmand and Rob J. de Haan},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2015},
  volume={87},
  pages={611 - 619}
}
Cognitive impairment is present in approximately 30% of patients with amyotrophic lateral sclerosis (ALS) and, especially when severe, has a negative impact on survival and caregiver burden. Our 2010 meta-analysis of the cognitive profile of ALS showed impairment of fluency, executive function, language and memory. However, the limited number of studies resulted in large confidence intervals. To obtain a more valid assessment, we updated the meta-analysis and included methodological… 

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References

SHOWING 1-10 OF 44 REFERENCES

The cognitive profile of amyotrophic lateral sclerosis: A meta-analysis

In conclusion, the diversity of cognitive problems in ALS seems greater than was previously thought, and patients may suffer from cognitive impairment in multiple domains, including memory dysfunction.

Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy

The lower educational attainment in patients with ALS-FTD indicated a possible role of cognitive reserve in ALS-related cognitive impairment, in keeping with a previous Irish study, despite the largely different genetic background of the two populations.

Prevalence and patterns of cognitive impairment in sporadic ALS

These data confirm the presence of cognitive impairment in 50% of patients with ALS and particularly implicate executive dysfunction and mild memory decline in the disease process and have features consistent with FTD.

An observational study of cognitive impairment in amyotrophic lateral sclerosis.

Demented patients with ALS showed predominant impairment in free recall, executive function, and naming, with relative preservation of attention, psychomotor speed, and visuospatial function, as well as increasing ALS severity and declining verbal fluency performance.

A prospective cohort study of neuropsychological test performance in ALS

  • P. GordonR. Goetz H. Mitsumoto
  • Psychology, Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2010
The strongest neuropsychological predictors of cognitive status were measures of executive, episodic memory and language function, and older age and more severe ALS were associated with impairment.

The effects of executive and behavioral dysfunction on the course of ALS

Survival is significantly shorter among patients with ALS-FTLD than with classic ALS, and patients with FTLD are twice as likely to be noncompliant.

[Cognitive impairment in amyotrophic lateral sclerosis].

A comparison of estimates by different scores of emotional state and quality of life (the Hamilton depression scale, CNSLS, ALSAQ40) allows to conclude that CC had no influence on the emotional state of ALS patients and their totalquality of life.

Cognition, Behavior, and Respiratory Function in Amyotrophic Lateral Sclerosis

Results suggest that the respiratory insufficiency of ALS patients may potentially produce irreversible deficits in executive functioning; yet once treated, impairments in more basic cognitive abilities may be less evident.

Subcortical structures in amyotrophic lateral sclerosis

Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis

  • M. StrongG. Grace D. Figlewicz
  • Psychology, Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2009
Recommendations arising from an international research workshop on frontotemporal dementia (FTD) and ALS address the requirement for a concise clinical diagnosis of the underlying motor neuron disease, defining the cognitive and behavioural dysfunction, and identifying the presence of disease modifiers.