The cognitive profile of ALS: a systematic review and meta-analysis update

@article{Beeldman2015TheCP,
  title={The cognitive profile of ALS: a systematic review and meta-analysis update},
  author={E. Beeldman and J. Raaphorst and M. Klein Twennaar and M. de Visser and B. Schmand and R. D. de Haan},
  journal={Journal of Neurology, Neurosurgery & Psychiatry},
  year={2015},
  volume={87},
  pages={611 - 619}
}
  • E. Beeldman, J. Raaphorst, +3 authors R. D. de Haan
  • Published 2015
  • Psychology, Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
  • Cognitive impairment is present in approximately 30% of patients with amyotrophic lateral sclerosis (ALS) and, especially when severe, has a negative impact on survival and caregiver burden. Our 2010 meta-analysis of the cognitive profile of ALS showed impairment of fluency, executive function, language and memory. However, the limited number of studies resulted in large confidence intervals. To obtain a more valid assessment, we updated the meta-analysis and included methodological… CONTINUE READING
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