The cognitive profile of ALS: a systematic review and meta-analysis update

@article{Beeldman2015TheCP,
  title={The cognitive profile of ALS: a systematic review and meta-analysis update},
  author={Emma Beeldman and Joost Raaphorst and Michelle Klein Twennaar and Marianne de Visser and Ben Schmand and Rob J. de Haan},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2015},
  volume={87},
  pages={611 - 619}
}
Cognitive impairment is present in approximately 30% of patients with amyotrophic lateral sclerosis (ALS) and, especially when severe, has a negative impact on survival and caregiver burden. Our 2010 meta-analysis of the cognitive profile of ALS showed impairment of fluency, executive function, language and memory. However, the limited number of studies resulted in large confidence intervals. To obtain a more valid assessment, we updated the meta-analysis and included methodological… Expand
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