The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.

@article{Um2010TheCD,
  title={The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.},
  author={Hee Jung Um and Jung Hwa Oh and Yoon-Nyun Kim and Young Hyun Choi and Sang Hyun Kim and Jong-Wook Park and Taeg Kyu Kwon},
  journal={Chemico-biological interactions},
  year={2010},
  volume={186 1},
  pages={36-42}
}
Kahweol, a coffee-specific diterpene, found in the beans of Coffea arabica, has potent anti-carcinogenic, anti-tumor, and anti-inflammatory properties. TRAIL is a potential anti-cancer compound that induces apoptosis in a wide variety of cancer cells, but not in most normal human cell types. In the present study, we show that kahweol sensitizes human renal cancer cells, but not normal human mesangial cells, to TRAIL-mediated apoptosis. Moreover, treatment with a combination of kahweol and TRAIL… CONTINUE READING

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