The coenzyme/protein pair and the molecular evolution of life.

  title={The coenzyme/protein pair and the molecular evolution of life.},
  author={Andreas Kirschning},
  journal={Natural product reports},
  • A. Kirschning
  • Published 18 November 2020
  • Biology
  • Natural product reports
Covering: up to 2020What was first? Coenzymes or proteins? These questions are archetypal examples of causal circularity in living systems. Classically, this "chicken-and-egg" problem was discussed for the macromolecules RNA, DNA and proteins. This report focuses on coenzymes and cofactors and discusses the coenzyme/protein pair as another example of causal circularity in life. Reflections on the origin of life and hypotheses on possible prebiotic worlds led to the current notion that RNA was… 

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