The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia.

@article{Liou2008TheCP,
  title={The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia.},
  author={Y J Liou and Y Wang and Ji-Yih Chen and M Chen and T Chen and Y-M Bai and Cheng-Chieh Lin and D Liao and I-C Lai},
  journal={European journal of neurology},
  year={2008},
  volume={15 12},
  pages={1406-8}
}
BACKGROUND Tardive dyskinesia (TD) is a severe and potentially irreversible adverse effect of long-term antipsychotic treatment. Typical antipsychotics are commonly binding to the dopamine receptor D2 (DRD2), but the occurrence of antipsychotic-induced TD is rather delayed; therefore, the development of TD may be associated with mediators or signalling complexes behind DRD2, such as beta-arrestin 2 (ARRB2), an important mediator between DRD2 and serine-threonine protein kinase (AKT) signal… CONTINUE READING