The coagulopathy of chronic liver disease.

  title={The coagulopathy of chronic liver disease.},
  author={Armando Tripodi and Pier Mannuccio Mannucci},
  journal={The New England journal of medicine},
  volume={365 2},
opposing drivers (Fig. 1), but the mechanistic significance of the parallel decrease of both procoagulants and anticoagulants in patients with chronic liver disease escaped attention for many years. As a consequence, chronic liver disease is still considered the epitome of acquired bleeding disorders and is featured as such in most hematology textbooks. The basic laboratory tests of coagulation (i.e., measurement of the prothrombin time and activated partial-thromboplastin time) have been used… 

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