The coagulopathy of chronic liver disease.

@article{Tripodi2011TheCO,
  title={The coagulopathy of chronic liver disease.},
  author={A. Tripodi and P. Mannucci},
  journal={The New England journal of medicine},
  year={2011},
  volume={365 2},
  pages={
          147-56
        }
}
opposing drivers (Fig. 1), but the mechanistic significance of the parallel decrease of both procoagulants and anticoagulants in patients with chronic liver disease escaped attention for many years. As a consequence, chronic liver disease is still considered the epitome of acquired bleeding disorders and is featured as such in most hematology textbooks. The basic laboratory tests of coagulation (i.e., measurement of the prothrombin time and activated partial-thromboplastin time) have been used… Expand
646 Citations

Paper Mentions

Interventional Clinical Trial
Recently it has been acknowledged that cirrhotic patients present with "rebalanced hemostasis" that results from decreased levels of both pro-coagulant and anti-coagulant factors… Expand
ConditionsCoagulopathy, Liver Cirrhosis
InterventionOther
Interventional Clinical Trial
The aim of this study is to compare three different blood transfusion strategies for coagulopathy correction before central venous catheterization in patients with chronic liver… Expand
ConditionsLiver Cirrhosis
InterventionOther
Coagulopathy in Cirrhosis
Liver disease, coagulopathies and transfusion therapy.
The coagulation system in patients with end‐stage liver disease
  • D. Valla, P. Rautou
  • Medicine
  • Liver international : official journal of the International Association for the Study of the Liver
  • 2015
Hematological Issues in Liver Disease
Coagulation Homeostasis in Liver Disease
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