The co-expression of c-myc and p53 increases and reaches a plateau early in oral oncogenesis.

@article{Papakosta2006TheCO,
  title={The co-expression of c-myc and p53 increases and reaches a plateau early in oral oncogenesis.},
  author={Veronica Papakosta and Eleftherios G Vairaktaris and Antonis Vylliotis and Spyridoula Derka and Emeka Nkenke and Stavros Vassiliou and Andreas M. Lazaris and Constantinos Mourouzis and Georgios E. Rallis and Sofia Spyridonidou and Sofia Anagnostopoulou and Despina Perrea and Ismini A Donta and Christos Yapijakis and Efstratios S. Patsouris},
  journal={Anticancer research},
  year={2006},
  volume={26 4B},
  pages={2957-62}
}
BACKGROUND The balance between cell proliferation and apoptosis plays a significant role in cancer development. The expressions of the p53 and c-myc genes, both strongly related to cell proliferation and apoptosis, were studied in sequential histological grades of oral carcinogenesis in an animal model. MATERIALS AND METHODS Thirty-seven hamsters were divided into three groups (A,B,C), which were treated with 9,10-dimethyl-1,2-benzanthracene and sacrificed at 10,14 or 19 weeks, respectively… CONTINUE READING
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