The clustering of axonal sodium channels during development of the peripheral nervous system.

@article{Vabnick1996TheCO,
  title={The clustering of axonal sodium channels during development of the peripheral nervous system.},
  author={I Vabnick and Slavko Novakovi{\'c} and Simon R. Levinson and Melitta Schachner and Peter G Shrager},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 16},
  pages={
          4914-22
        }
}
The distribution of Na+ channels in rat peripheral nerve was measured during development by using immunofluorescence. Small segments of sciatic nerve from postnatal day 0-13 (P0-P13) pups were labeled with an antibody raised against a well conserved region of the vertebrate Na+ channel. At day P0 axons contained almost no Na+ channel aggregates. The number of clusters increased dramatically throughout the first week. In almost all cases Na+ channels clustered in the vicinity of Schwann cell… CONTINUE READING

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